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KMID : 0387420120230010115
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Korean Society of Oriental Neuropsychiatry
2012 Volume.23 No. 1 p.115 ~ p.128
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Preventive Effects of Santalum album L. Extracts on Oxidation, Platelet Aggregation and Thrombosis
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Sung Yung-Wei
Lee Ji-Hyun
Song Kyoo-Ju
Koo Byung-Su
Kim Geun-Woo
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Abstract
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Objectives: To evaluate the in vitro scavenging activity, inhibitory effect of LDL oxidation of pro-oxidant reactive species, anti-platelet aggregative effects and anti-thrombosis effects in response to treatment with SA using various screening methods including biological and non-biological oxidants.
Methods: The antioxidant activity concerning extract from SA was studied with in vitro methods by measuring the antioxidant activity by TEAC, measuring the scavenging effects on reactive oxygen species (ROS) [superoxide anion, hydroxyl radical] and on reactive nitrogen species (RNS) [nitric oxide and peroxynitrite] as well as measuring the inhibitory effect on Cu²+ -induced human LDL oxidation and the inhibitory effect on thrombin-induced platelet aggregation and thrombosis.
Results: SA extracts were found to have a potent scavenging activity regarding oxidative stress as well as an inhibitory effect towards LDL oxidation, platelet aggregation, and thrombosis.
Conclusions: The SA extracts have anti-oxidative and anti-atherosclerotic effects in vitro system, which can be used for developing pharmaceutical drugs against oxidative stress and atherosclerosis.
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KEYWORD
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Santalum album L., Oxidation, Platelet aggregation, Thrombosis
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